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Invitrogen™ CCL5 (RANTES) Monoclonal Antibody (R6G9), eBioscience™
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 14708582

Description
Description: RANTES (Regulated on Activation, Normal T Expressed and Secreted) is an 8kD member of the C-C family of chemkines (CCL5). It is a proinflammatory chemoattractant for several cell types including CD4+ T cells, monocytes and eosinophils. In contrast to other members of the chemokine superfamily, RANTES has been observed to be downregulated upon activation in T cells. In other secreting cells, upregulation is observed in response to activation. Applications Reported: This R6G9 antibody has been reported for use in immunoblotting (WB). Applications Tested: This R6G9 antibody has been tested by immunoblot on lysates of LPS-activated Raw 264.7 cells. This can be used at less than or equal to 2 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
Specifications
CCL5 (RANTES) | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P30882 | |
CCL5 | |
Affinity chromatography | |
RUO | |
20304 | |
4°C | |
Liquid |
Western Blot | |
R6G9 | |
Unconjugated | |
CCL5 | |
beta-chemokine RANTES; CC chemokine; C-C motif chemokine 5; C-C motif chemokine ligand 5; CCL5; chemokine (C-C motif) ligand 5; D17S136E; EoCP; eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; RANTES; RANTES protein; RANTES(3-68); RANTES(4-68); regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; Scya5; SIS d; SISd; SIS-delta; SISd; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; Unknown (protein for MGC:127014) | |
Mouse | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG1 |
Safety and Handling
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