CCM2/Malcavernin Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS11817R

Catalog No. 50-198-1693

Description

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CCM2/Malcavernin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCM2
• Gene Alias: BC029157; C7orf22; Ccm2; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformation 2 homolog; Cerebral cavernous malformations 2 protein; Cerebral cavernous malformations protein 2 homolog; Malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; Osm; Osmosensing scaffold for MEKK3; PP10187
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 83605
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q9BSQ5
• Gene Symbols: CCM2
• Immunogen: KLH conjugated synthetic peptide derived from human Malcavernin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG