Invitrogen™ CCM2 Monoclonal Antibody (OTI2E4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA525668

Catalog No. PIMA525668

Description

CCM2 Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CCM2
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BSQ5
• Gene Symbols: CCM2
• Immunogen: Full length human recombinant protein of CCM2 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: OTI2E4
• Conjugate: Unconjugated
• Gene: CCM2
• Gene Alias: BC029157; C7orf22; Ccm2; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformation 2 homolog; cerebral cavernous malformations 2 protein; Cerebral cavernous malformations protein 2 homolog; malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; Osm; osmosensing scaffold for MEKK3; PP10187
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 83605
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid