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CCM2 Monoclonal Antibody (OTI3B7), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA503397

Encompass_Preferred

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Catalog No. 50-167-4299


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Description

Description

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

CCM2
Monoclonal
0.24 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Q9BSQ5
CCM2
Full length human recombit protein of human CCM2 produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG1
Immunocytochemistry, Immunofluorescence, Western Blot
OTI3B7
Unconjugated
CCM2
C7orf22, OSM, PP10187
Mouse
Affinity Chromatography
RUO
83605
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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