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Invitrogen™ CCM2 Polyclonal Antibody
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Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518604

Catalog No. PIPA518604


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Description

Description

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CCM2
Polyclonal
Unconjugated
CCM2
BC029157; C7orf22; Ccm2; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformation 2 homolog; cerebral cavernous malformations 2 protein; Cerebral cavernous malformations protein 2 homolog; malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; Osm; osmosensing scaffold for MEKK3; PP10187
Goat
Ammonium sulfate precipitation
RUO
305505, 83605
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Flow Cytometry, Western Blot, Immunocytochemistry
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q9BSQ5
CCM2
Synthetic peptide sequence (KGEKSRDKKAHEK) corresponding to the internal amino acids of CCM2 (aa 23-36).
100 μg
Primary
Human, Rat
Antibody
IgG
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