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Invitrogen™ CCM2 Polyclonal Antibody
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Catalog No. PIPA5111607
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100 μL
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PIPA5111607 100 μL
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Catalog No. PIPA5111607 Supplier Invitrogen™ Supplier No. PA5111607
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KDSQHFENFL ETIGVKDGRG IITDSFGRHR RALSTTSSST TNGNRATGSS DDRSAPSEGD EWDRMISDIS SDVEALGCSM DQDS Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 94%.

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCM2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CCM2
Gene Accession No. Q9BSQ5
Gene Alias BC029157; C7orf22; Ccm2; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformation 2 homolog; cerebral cavernous malformations 2 protein; Cerebral cavernous malformations protein 2 homolog; malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; Osm; osmosensing scaffold for MEKK3; PP10187
Gene Symbols CCM2
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human CCM2. Recombinant protein control fragment (Product #RP-107456).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83605
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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