CCM2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5282	Proteintech Group Inc 262701AP150UL	150 μL

Description

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CCM2
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9BSQ5
• Gene ID (Entrez): 83605
• Immunogen: CCM2 Fusion Protein Ag24233
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CCM2

• Concentration: 0.24 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: C7orf22, CCM2, Malcavernin, OSM, PP10187
• Gene Symbols: CCM2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody