Invitrogen™ CCR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114712

Catalog No. PIPA5114712

Description

Antibody detects endogenous levels of total CCR1.

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Specifications

• Antigen: CCR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCR1
• Gene Alias: C-C chemokine receptor type 1; C-C CKR-1; C-C motif chemokine receptor 1; CC-CKR-1; Ccr1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; CKR1; CKR-1; CMKBR1; CMKR1; HM145; LD78 receptor; macrophage inflammatory protein 1-alpha receptor; macrophage inflammatory protein-1 alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; MIP1aR; Mip-1a-R; RANTES receptor; RANTES-R; SCYAR1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1230
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P32246
• Gene Symbols: CCR1
• Immunogen: A synthesized peptide derived from human CCR1(Accession P32246), corresponding to amino acid residues M1-Y41.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG