Invitrogen™ CCR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533392

Catalog No. PIPA533392

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Monkey, Hamster (89%) Marmoset, Mouse (83%).

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Specifications

• Antigen: CCR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCR1
• Gene Alias: C-C chemokine receptor type 1; C-C CKR-1; C-C motif chemokine receptor 1; CC-CKR-1; Ccr1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; CKR1; CKR-1; CMKBR1; CMKR1; HM145; LD78 receptor; macrophage inflammatory protein 1-alpha receptor; macrophage inflammatory protein-1 alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; MIP1aR; Mip-1a-R; RANTES receptor; RANTES-R; SCYAR1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1230
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P32246
• Gene Symbols: CCR1
• Immunogen: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCR1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG