Invitrogen™ CCR1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA120688

Catalog No. PIPA120688

Description

Recommended positive controls: Immunocytochemistry on human peripheral blood leukocytes. This antibody does not cross react with mouse CCR1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

Specifications

• Antigen: CCR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCR1
• Gene Alias: C-C chemokine receptor type 1; C-C CKR-1; C-C motif chemokine receptor 1; CC-CKR-1; Ccr1; CCR-1; CD191; chemokine (C-C motif) receptor 1; chemokine (C-C) receptor 1; CKR1; CKR-1; CMKBR1; CMKR1; HM145; LD78 receptor; macrophage inflammatory protein 1-alpha receptor; macrophage inflammatory protein-1 alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; MIP1aR; Mip-1a-R; RANTES receptor; RANTES-R; SCYAR1
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1230
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.1% sodium azide
• Gene Accession No.: P32246
• Gene Symbols: CCR1
• Immunogen: Synthetic peptide corresponding to residues T(7) E D Y D T T T E F D Y G D A T P C(24) of human CCR1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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