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CCR2 Polyclonal Antibody, Invitrogen™

Catalog No. PA121623
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100 μg
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Catalog No. Quantity
PA121623 100 μg
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Catalog No. PA121623 Supplier Thermo Scientific Supplier No. PA121623

Description

Goat Polyclonal Antibody

Recommended positive controls: Human peripheral blood cells or section of spleen.. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCR2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 10mM potassium phosphate with 140mM NaCl, 1mg/mL BSA and 0.1% sodium azide
Gene Ccr2
Gene Accession No. P41597
Gene Alias C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; C-C motif chemokine receptor 2; Cc-ckr2; CC-CKR-2; Ccr2; CCR-2; Ccr2a; CCR2B; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; chemokine receptor CCR2; Ckr2; Ckr2a; Ckr2b; CMKBR2; hCG_14621; JE/FIC receptor; Mcp1 receptor; MCP-1 receptor; Mcp1r; MCP-1-R; MIP-1 alphaR; mJe-r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Symbols Ccr2
Host Species Goat
Immunogen Synthetic peptide corresponding to residues C G E E V T T F F D Y D Y G A P C H K F D V K Q of human CCR2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 729230
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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