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CCR2a Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501730757 Shop All Proteintech Group Inc Products
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50-173-0757 150 μL
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Catalog No. 50-173-0757 Supplier Proteintech Group Inc Supplier No. 161531AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody 16153-1-AP is raised against the peptide of 344-358 amino acids of CCR2a. It is specific to CCR2a.

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

Specifications

Antigen CCR2a
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CCR2
Gene Accession No. P41597
Gene Alias C C chemokine receptor type 2, C C CKR 2, CC CKR 2, CCR 2, CCR2, CCR2a, CCR2b, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP 1 R
Gene Symbols CCR2
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 729230
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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