Invitrogen™ CCR4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599885

Catalog No. PIPA599885

Description

Antibody detects endogenous levels of total CCR4.

CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

Specifications

• Antigen: CCR4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ccr4
• Gene Alias: C-C chemokine receptor 4; C-C chemokine receptor type 4; C-C CKR-4; C-C motif chemokine receptor 4; CC-CKR-4; Ccr4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; CHEMR1; ChemR13; CKR4; Cmkbr4; fusin; HGCN:14099; K5-5; LESTR; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293; Sdf1r
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1233, 12773
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P51679, P51680
• Gene Symbols: Ccr4
• Immunogen: A synthesized peptide derived from human CCR4(Accession P51679), corresponding to amino acid residues M1-L48.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG