Invitrogen™ CCR6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533399

Catalog No. PIPA533399

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Mouse, Rat, Horse (80%).

CD196, also known as CCR6, is a member of the beta chemokine receptor family and is characterized by a seven transmembrane structure similar to G protein-coupled receptors. This receptor uniquely binds to macrophage inflammatory protein 3 alpha (MIP-3alpha/CCL20), which acts as a chemoattractant for dendritic cells, effector/memory T cells, and B cells. CCR6 is preferentially expressed by immature dendritic cells and memory T cells, playing a crucial role in host defense and inflammation at epithelial sites. It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it regulates the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Additionally, CCR6 has been implicated in the differentiation of Th17 cells and the development of CD4+FoxP3+ regulatory T cells, highlighting its role in immune regulation. Alternatively spliced transcript variants encoding the same protein have been described for this gene, further emphasizing its functional diversity in immune processes.

Specifications

• Antigen: CCR6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCR6
• Gene Alias: BN-1; CC chemokine receptor 6; C-C chemokine receptor type 6; C-C CKR-6; C-C motif chemokine receptor 6; CC-CKR-6; CCR6; CCR-6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; chemokine receptor-like 3; CKR6; CKRL3; CKR-L3; Cmkbr6; DCR2; DRY6; DRY-6; G protein-coupled receptor 29; GPR29; GPRCY4; GPR-CY4; G-protein coupled receptor 29; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22; STRL22
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1235
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P51684
• Gene Symbols: CCR6
• Immunogen: Synthetic 20 amino acid peptide from C-terminus of human CCR6.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG