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Invitrogen™ CCR7 Chimeric Recombinant Rabbit Monoclonal Antibody (4B12)
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Catalog No. PIMA548306
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200 μg
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PIMA548306 200 μg
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Catalog No. PIMA548306 Supplier Invitrogen™ Supplier No. MA548306
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation.

CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CCR7 Chimeric
Applications Flow Cytometry, Functional Assay, Immunoprecipitation, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 4B12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Ccr7
Gene Accession No. P47774
Gene Alias BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
Gene Symbols Ccr7
Host Species Rabbit
Immunogen This antibody was raised by immunizing rats with mouse CCR7 antigen.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12775
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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