Invitrogen™ CCR8 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA129909

Catalog No. PIPA129909

Description

Recommended positive controls: Human K562 cells (ICC)and human spleen (IHC-P). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.

Specifications

• Antigen: CCR8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCR8
• Gene Alias: C-C; CC chemokine receptor 8; CC chemokine receptor CHEMR1; C-C chemokine receptor type 8; C-C CKR-8; C-C motif chemokine receptor 8; CC-chemokine receptor chemr1; CC-CKR-8; CCR8; CCR-8; cd198; CDw198; chemokine (C-C motif) receptor 8; chemokine (C-C) receptor 8; chemokine (C-C) receptor-like 2; chemokine receptor-like 1; CKR-8; CKRL1; CKR-L1; Cmkbr8; CMKBRL2; CY6; GPRCY6; GPR-CY6; mCCR8; MGC129966; MGC129973; TER1
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1237
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.01M potassium phosphate with 0.1% BSA, 0.14M NaCl and 0.1% sodium azide
• Gene Accession No.: P51685
• Gene Symbols: CCR8
• Immunogen: Synthetic peptide CYSFYNQQTLK corresponding to second extracellular domain sequence of human CCR8 (aa 183-193).
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov