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  6. Invitrogen™ CD101 Monoclonal Antibody (Moushi101), NovaFluor™ Yellow 730, eBioscience™, Invitrogen™ 

Invitrogen™ CD101 Monoclonal Antibody (Moushi101), NovaFluor™ Yellow 730, eBioscience™, Invitrogen™

Catalog No. M045T02Y07A
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M045T02Y07A 25 μg
M045T03Y07A 100 μg
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Description

Rat Monoclonal Antibody

CD101, also known as the V7 antigen, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is characterized by 7 Ig-like IgV domains and a short cytoplasmic tail with several phosphorylation sites. CD101 forms a disulfide-linked homodimer, although its precise function remains unknown. Expression of CD101 is observed on monocytes, granulocytes, dendritic cells, Langerhans cells, and activated T cells. It is also found on a subset of CD25+Foxp3+ regulatory T cells, which exhibit higher suppressive properties in vitro and in vivo. CD101 plays a role in modulating immune responses. Cross-linking CD101 can antagonize TCR/CD3-mediated lymphocyte activation, while CD101+ CD28+ T cells are highly responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can enhance proliferation, suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. In mice, CD101 is expressed on a subpopulation of regulatory T cells (CD4+, CD25+, Foxp3+) with high suppressor activity. In humans, CD101 expression on peripheral blood mononuclear cells (PBMCs) stains approximately 30% of Foxp3+ cells, although studies have not confirmed higher suppressor activity in the human CD101+ population.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD101
Applications Flow Cytometry
Classification Monoclonal
Clone Moushi101
Concentration 0.1 mg/mL
Conjugate NovaFluor Yellow 730
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD101
Gene Accession No. A8E0Y8
Gene Alias Cd101; CD101 antigen; CD101 molecule; cell surface glycoprotein V7; EWI immunoglobulin subfamily member EWI-101; EWI101; EWI-101; Glu-Trp-Ile EWI motif-containing protein 101; Gm1016; Gm734; IGSF2; Immunoglobulin superfamily member 2; immunoglobulin superfamily, member 2; leukocyte surface protein; RP11-27K13.2; V7
Gene Symbols CD101
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 630146
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG2a κ
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