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Invitrogen™ CD103 (Integrin alpha E) Recombinant Rabbit Monoclonal Antibody (BLR171J)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544527

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Catalog No. PIMA544527


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Description

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

CD103, also known as ITGAE or Integrin alpha E, is a molecule that non-covalently associates with integrin beta 7 to form a heterodimeric integral membrane protein. This protein is part of the integrin family, characterized by an alpha chain and a beta chain. Specifically, CD103 includes a 150 kDa alpha chain and a 120 kDa beta chain, with the alpha integrin undergoing post-translational cleavage in the extracellular domain to yield disulfide-linked heavy and light chains. CD103 is primarily expressed on mucosa-associated T lymphocytes, intraepithelial lymphocytes (IELs), and activated cells, as well as a subset of TGF beta-1 cells. It is preferentially found in human intestinal IELs, where it plays a role in adhesion and may serve as an accessory molecule for IEL activation. CD103 binds to epithelial cell antigen E-cadherin, mediating the homing of lymphocytes to the intestinal epithelium. In peripheral blood and lymphoid organs, CD103 is expressed by 0.5 to 2% of resting lymphocytes, and its expression can be upregulated in vitro by stimulating human T cells with mitogens. CD103 is also expressed by hairy cell leukemia (HCL) and some chronic B cell lymphocytic leukemias. The CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD103 (Integrin alpha E)
Recombinant Monoclonal
1 mg/mL
BBS with 0.09% sodium azide; pH 8.2
P38570
Itgae
Peptide representing a region between residue 400 and 450 of Human Integrin alpha-E (aka CD103).
100 μL
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
BLR171J
Unconjugated
Itgae
A530055J10; alpha-E1; alpha-M290; aM290; antigen CD103; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; DC; DCs; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha E; integrin alpha E, epithelial-associated; integrin alpha E1, epithelial-associated; integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; Integrin alpha-IEL; integrin subunit alpha E; integrin, alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); integrin, alpha E, epithelial-associated; Intregrin alpha E2; Itgae; MGC141996; Mucosal lymphocyte 1 antigen
Rabbit
Purified
RUO
3682
4°C
Liquid
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