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Invitrogen™ CD105 (Endoglin) Monoclonal Antibody (MEM-229), Biotin
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Catalog No. PIMA528545
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100 μg
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Catalog No. Quantity
PIMA528545 100 μg
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Catalog No. PIMA528545 Supplier Invitrogen™ Supplier No. MA528545
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD105 (Endoglin)
Applications Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone MEM-229
Concentration 1 mg/mL
Conjugate Biotin
Formulation PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene ENG
Gene Accession No. P17813, P37176
Gene Alias AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
Gene Symbols ENG
Host Species Mouse
Immunogen Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2022, 397096
Target Species Human, Pig
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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