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  6. Invitrogen™ CD105 (Endoglin) Monoclonal Antibody (SN6), APC-eFluor™ 780, eBioscience™, Invitrogen™ 

Invitrogen™ CD105 (Endoglin) Monoclonal Antibody (SN6), APC-eFluor™ 780, eBioscience™, Invitrogen™

Catalog No. 47105741
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47-105-742 100 Tests
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Catalog No. 47-105-741 Supplier Invitrogen™ Supplier No. 47105741

Description

Mouse Monoclonal Antibody

Description: The SN6 monoclonal antibody reacts with human CD105, also known as Endoglin. CD105, an approximately 90 kDa disulfide-linked homodimer is expressed by vascular endothelial cells and some bone marrow cells and activated macrophages. It is suggested that CD105 functions in adhesion and embryonic angiogenesis. Applications Reported: This SN6 antibody has been reported for use in flow cytometric analysis. Applications Tested: This SN6 antibody has been pre-diluted and tested by flow cytometric analysis of U937 cell line. This may be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. APC-eFluor 780 emits at 780 nm and is excited with the Red laser (633-647 nm). Please make sure that your instrument is capable of detecting this fluorochrome. Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222-49) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No. 00-5333-57) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD105 (Endoglin)
Applications Flow Cytometry
Classification Monoclonal
Clone SN6
Concentration 5 μL/Test
Conjugate APC-eFluor 780
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene ENG
Gene Accession No. P17813
Gene Alias AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
Gene Symbols ENG
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2022
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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