Invitrogen™ CD105 Monoclonal Antibody (209701)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523894

Catalog No. PIMA523894

Description

In Western blots, this antibody shows 100% cross-reactivity with recombinant human Endoglin. Reconstitute at 0.5 mg/mL in sterile PBS.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

Specifications

• Antigen: CD105
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q63961
• Gene Symbols: ENG
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Endoglin Glu21-Gly581 (predicted).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: 209701
• Conjugate: Unconjugated
• Gene: ENG
• Gene Alias: AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 13805
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized