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Invitrogen™ CD105 Monoclonal Antibody (MEM-229)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119408

Catalog No. 01-676-156


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Description

Description

This antibody recognizes an extracellular epitope of CD105 (Endoglin), a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy. Western Blot: non-reducing conditions; Immunohistochemistry (Frozen): acetone fixation.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD105
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P17813, P37176
ENG
Recombinant Vaccinia virus containing human CD105 (L-isoform) cDNA.
100 μg
Primary
Human, Pig
Antibody
IgG2a
Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
MEM-229
Unconjugated
ENG
AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
Mouse
Protein A
RUO
2022, 397096
4°C, do not freeze
Liquid
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