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  6. Invitrogen™ CD115 (c-fms) Monoclonal Antibody (AFS98), NovaFluor™ Red 710, eBioscience™, Invitrogen™ 

Invitrogen™ CD115 (c-fms) Monoclonal Antibody (AFS98), NovaFluor™ Red 710, eBioscience™, Invitrogen™

Catalog No. M041T02R04A
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25 μg
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M041T02R04A 25 μg
M041T03R04A 100 μg
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Catalog No. M041T02R04A Supplier Invitrogen™ Supplier No. M041T02R04A
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Description

Rat Monoclonal Antibody

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD115 (c-fms)
Applications Flow Cytometry
Classification Monoclonal
Clone AFS98
Concentration 0.1 mg/mL
Conjugate NovaFluor Red 710
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Csf1r
Gene Accession No. P09581
Gene Alias AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms
Gene Symbols Csf1r
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12978
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG2a κ
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