MilliporeSigma™ CD117 (c-Kit), Rat, PE-Cy7, Clone: ACK2,

Catalog No.	Quantity	Conjugate
MABF1499MI	100 μg	PE-Cyanine7

Catalog No. MABF1499MI Supplier MilliporeSigma™ Supplier No. MABF1499

Description

Rat Monoclonal Antibody

The ACK2 antibody is specific for CD117, also called c-Kit, a 145kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. Please choose the appropriate format for each application. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.

Specifications

• Antigen: CD117 (c-Kit)
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: ACK2
• Concentration: Please refer to lot specific datasheet.
• Conjugate: PE-Cyanine7
• Formulation: Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
• Gene: Kit, SI
• Gene Accession No.: P05532
• Host Species: Rat
• Immunogen: Immunogen information for this antibody is proprietary information.
• Purification Method: Purified by size-exclusion chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Inflammation & Immunology
• Primary or Secondary: Primary
• Target Species: Mouse
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2°-8°C and protected from prolonged exposure to light. Do not freeze.
• Form: Purified

For Research Use Only. Not for use in diagnostic procedures.