CD117 Mouse anti-Human, PE, Clone: YB5.B8, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 555714

Catalog No. BDB555714

Description

The YB5.B8 monoclonal antibody specifically binds to CD117. CD117, also known as c-Kit, is a 145 kDa cell-surface glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes. CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF) or mast cell growth factor (MGF). The interaction of c-Kit and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of the YB5.B8 antibody to block the binding of c-Kit ligand is still controversial.

Specifications

• Antigen: CD117
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Description: KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: YB5.B8
• Conjugate: PE
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Acute myelocytic leukemia blasts
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Human
• Isotype: IgG1 κ

For Research Use Only.