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Description
The G-25.2 monoclonal antibody specifically recognizes CD11a which is also known as Leukocyte function-associated molecule 1 alpha chain (LFA-1A or LFA-1α). CD11a is a ∼180 kDa type I transmembrane glycoprotein that is encoded by ITGAL (Integrin subunit alpha L) that belongs to integrin α-chain family. CD11a is a leucocyte adhesion receptor that noncovalently complexes with CD18 to form the LFA-1 heterodimer (CD11a/CD18) which binds to intercellular adhesion molecules (ICAMs) expressed on target tissues including ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), ICAM-4, or ICAM-5. The CD11a antigen is expressed on virtually all normal peripheral blood leucocytes. It is essential for many immune responses that require cell-to-cell contact, such as lymphocyte adhesion, natural killer (NK) and T-lymphocyte cytolysis, and T lymphocyte proliferation. Activation of lymphocytes through the T-cell antigen receptor (TCR) upregulates LFA-1 function, converting the antigen to a high-avidity state. Expression of LFA-1 on monocytes is upregulated by γ-interferon (IFN-γ). While normal cells possess both the α and β LFA-1 chains, cells of subjects with some leukemias, lymphomas, or leucocyte adhesion deficiency (LAD) may lack the entire LFA-1 molecule or the α or β chain. The absence of LFA-1 on tumor cells may provide a mechanism for their escape from immune surveillance.
Specifications
Specifications
| Antigen | CD11a |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | G-25.2 |
| Conjugate | R718 |
| Host Species | Mouse |
| Quantity | 50 μg |
| Regulatory Status | RUO |
| Primary or Secondary | Primary |
| Target Species | Human |
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