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CD11b (Integrin αM) Rat anti-Mouse, Human, RB545, Clone: M1/70, BD Horizon™

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BDB569256 25 μg
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Catalog No. BDB569256 Supplier BD Biosciences Supplier No. 569256
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Description

Rat Monoclonal Antibody

The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi. Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes. Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface. The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis. Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.

CD11b (Integrin αM) Monoclonal antibody specifically detects CD11b (Integrin αM) in Mouse, Human samples. It is validated for Flow Cytometry
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11b (Integrin αM)
Applications Flow Cytometry
Classification Monoclonal
Clone M1/70
Concentration 0.2 mg/mL
Conjugate RB545
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Host Species Rat
Immunogen Mouse Splenic Cells
Purification Method Affinity Purified
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16409
Target Species Mouse, Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed.
Form Purified
Isotype IgG2b κ
Excitation/Emission Excitation Source: Blue 488 nm, Excitation Max: 496 nm, Emission Max: 545 nm
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