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CD11c Hamster anti-Mouse, BUV395, Clone: N418, BD Optibuild™

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BDB744180 50 μg
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Catalog No. BDB744180 Supplier BD Biosciences Supplier No. 744180
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Description

Armenian Hamster Monoclonal Antibody

The N418 monoclonal antibody specifically binds to CD11c, the Integrin alpha X (Integrin X, Itgax) chain of the heterodimeric gp150, 95 (CD11c/CD18, ) integrin that forms the complement receptor 4 (CR4). CD11c is a150 kDa type I transmembrane glycoprotein that is expressed on dendritic cells, CD4-CD8+ intestinal intraepithelial lymphocytes (IEL), and some NK cells and T cells. CD11c expression is upregulated on IEL and T cells following activation. Cells of the monocyte/macrophage lineage have been reported to express low levels of CD11c. The CD11c/CD18 integrin can bind to several ligands including iC3b, fibrinogen, and CD54. This integrin reportedly plays important roles in phagocytosis and in mediating cellular interactions during inflammation.

The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry. With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter. BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences. With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter. This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11c
Classification Monoclonal
Clone N418
Concentration 0.2mg/mL
Conjugate Brilliant Ultraviolet 395
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Itgax, Integrin alpha-X, Integrin αX, ITAX, CR4, Complement Receptor 4
Host Species Armenian Hamster
Immunogen Mouse Dendritic Cells
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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