Invitrogen™ CD11c Monoclonal Antibody (CBR-p150/4G1), eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ BMS112

Catalog No. 50-177-43

Description

Description: BMS112 detects CD11c from human samples. Integrin alpha X (CBR-p150/4G1) is a mouse monoclonal antibody raised againstIntegrin alpha X of human origin. The antibody can be used to stain aceton-fixed cryostat sections or cell smears. BMS112 is also suitable as primary antibody in immunofluorescence, flow cytometry. In functional assays the antibody inhibits binding between p150,95 and endothelial cells. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. Applications Tested: Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry (Frozen). Purity: >95%.

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

Specifications

• Antigen: CD11c
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P20702
• Gene Symbols: Itgax
• Immunogen: Rec. Human Podoplanin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry
• Clone: CBR-p150/4G1
• Conjugate: Unconjugated
• Gene: Itgax
• Gene Alias: AI449405; CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement component 3 receptor 4 subunit; complement receptor 4; Cr4; integrin alpha X; integrin alpha-X; integrin aX; integrin subunit alpha X; integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); Itgax; Leu M5; leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; N418; p150 95 integrin alpha chain; RGD1561123; SLEB6
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3687
• Content And Storage: 4°C
• Form: Liquid