CD123 Mouse anti-Human, FITC, Clone: 7G3, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB561694	BD Biosciences 561694	25 Tests
BDB558663	BD Biosciences 558663	100 Tests

Description

Reacts with human CD123, the 70kDa IL-3 receptor α chain (IL-3Rα), which associates with the 120-140kDa β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for
immunoprecipitation, western blot and immunofluorescent staining for flow cytometry. At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123.

Specifications

• Antigen: CD123
• Applications: Flow Cytometry
• Conjugate: FITC
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG2a κ
• Purification Method: Affinity Purified
• Description: IL3RA; IL-3RA; IL-3Rα; IL-3R-alpha; Interleukin-3 receptor subunit alpha

• Clone: 7G3
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: Human IL-3Ra-transfected cells
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.