Invitrogen™ CD13 Monoclonal Antibody (WM15)

Catalog No.	Quantity
PIMA544064	100 μg

Catalog No. PIMA544064 Supplier Invitrogen™ Supplier No. MA544064

Description

Mouse Monoclonal Antibody

This antibody The antibody WM15 recognizes an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors. Functional application: The antibody inhibits infection of cells by human coronavirus and inhibits aminopeptidase N activity of the CD13 molecule immunoprecipitants.

CD13, also known as ANPEP, is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on a wide variety of cell types and tissues. It is prominently found on monocytes and granulocytes in the blood, but not on lymphocytes. Additionally, CD13 is expressed on endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, placenta, and myeloid leukemia cells. As a metalloprotease, CD13 preferentially catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides. It plays a crucial role in various biological processes, including the degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and the adhesion and migration of cells. CD13 is also involved in extracellular matrix degradation, signal transduction, inflammatory responses, regulation of intercellular contact, cell motility, and vascularization. In the context of disease, CD13 is associated with the protection of leukemic cells against apoptosis and is linked to a poor prognosis in carcinomas. Furthermore, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.

Specifications

• Antigen: CD13
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: WM15
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.4
• Gene: ANPEP
• Gene Accession No.: P15144
• Gene Alias: alanyl (membrane) aminopeptidase; alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150); alanyl aminopeptidase; alanyl aminopeptidase, membrane; aminopeptidase; aminopeptidase Ey; Aminopeptidase M; aminopeptidase N; aminopeptidase N.; aminopeptidase N/CD13; Anpep; APDE; Apm; AP-M; APN; AP-N; bAPN; cAPN; Cd13; cluster of differentiation antigen 13 (CD13); fAPN; gp130; gp150; h AP-N; hAPN; kidney aminopeptidase M; kidney Zn peptidase; KZP; Lap1; Lap-1; leucine arylaminopeptidase 1; LOW QUALITY PROTEIN: aminopeptidase N; membrane alanine aminiopeptidase; membrane alanine aminopeptidase; membrane alanyl aminopeptidase; membrane protein p161; Microsomal aminopeptidase; myeloid plasma membrane glycoprotein CD13; p150; pAPN; PEPN; porcine aminopeptidase N; rAPN; rbAPN; Unknown (protein for MGC:126949)
• Gene Symbols: ANPEP
• Host Species: Mouse
• Immunogen: Human AML cells.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 290
• Target Species: Human, Monkey
• Content And Storage: 4°C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1