CD131 Mouse, anti-Human, R718, Clone: 3D7, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752168

Catalog No. BDB752168

Description

The 3D7 antibody reacts with CD131, the 120 kD common β chain (βc) which is shared with the receptor complexes for human granulocyte-macrophage colony stimulating factor (GM-CSFR), interleukin-3 (IL-3R) and interleukin-5 (IL-5R). Together with the α subunit of either the IL-3R (IL-3Rα), IL-5R (IL-5Rα), or GM- CSFR (GM-CSFRα), the common β chain forms high-affinity, signaling receptors for human IL-3, IL-5 and GM-CSF, respectively. Cell surface βc are expressed by a variety of different cell types including hematopoietic progenitor cells derived from pluripotent stem cells, monocytes, neutrophils, eosinophils, basophils, endothelial cells, fibroblasts, and Langerhans cells. The immunogen used to generate this hybridoma was cells co-transfected with expression vectors which contained cDNA for the human IL-3 α and β chains.

Specifications

• Antigen: CD131
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: 3D7
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Form: Liquid