Invitrogen™ CD134 (OX40) Monoclonal Antibody (OX40), APC, eBioscience™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 17134282

Catalog No. 50-112-9301

Description

Description: The monoclonal antibody OX40 reacts with rat CD134, a 50-kDa glycoprotein belonging to the TNFR superfamily. CD134, which is also known as OX40, is expressed on activated T cells, TH1, TH2, TH17, and Tregs, but not on naive CD4 or CD8 T cells or most memory cells. CD134 is also inducible on NKT cells, neutrophils, and NK cells. CD134 binds to CD252 (OX40L) to mediate T cell expansion and survival, as well as memory T cell generation. Finally, CD134 is involved in Treg suppression and tolerance. Applications Reported: This OX40 antibody has been reported for use in flow cytometric analysis. Applications Tested: This OX40 antibody has been tested by flow cytometric analysis of stimulated rat splenocytes. This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.

Specifications

• Antigen: CD134 (OX40)
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: P15725
• Gene Symbols: Tnfrsf4
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25572
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: OX40
• Conjugate: APC
• Gene: Tnfrsf4
• Gene Alias: ACT35; ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; IMD16; Ly-70; lymphoid activation antigene ACT35; MRC OX40; Ox40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 receptor; TNF receptor superfamily member 4; Tnfrsf4; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor superfamily, member 4; Txgp1; Txgp1l
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG2b κ