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Invitrogen™ CD137 (4-1BB) Monoclonal Antibody (2G1)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA542580
This item is not returnable.
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Description
Positive Control: A431, A549, LOVO, rat brain tissue, rat hippocampus tissue, human liver cancer tissue, mouse brain tissue, human tonsil tissue, Jurkat. Subcellular Location: Membrane. Extracellular space.
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Specifications
CD137 (4-1BB) | |
Monoclonal | |
2 mg/mL | |
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
P20334, Q07011 | |
TNFRSF9 | |
Recombinant full length protein. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
2G1 | |
Unconjugated | |
TNFRSF9 | |
4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 | |
Mouse | |
Protein A | |
RUO | |
21942, 3604, 500590 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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