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CD138 Rat anti-Mouse, PE, Clone: 281-2, BD

Rat Monoclonal Antibody

$158.70 - $426.00

Specifications

Antigen CD138
Clone 281-2
Concentration 0.2mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB561070
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BD Biosciences
561070
25 μg
Each for $158.70
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BDB553714
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BD Biosciences
553714
0.2 mg
Each for $426.00
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Description

Description

The 281-2 monoclonal antibody specifically binds to the core protein of CD138 (Syndecan-1), a cell-surface, integral membrane heparan sulfate- and chondroitin sulfate-containing proteoglycan that binds to interstitial extracellular matrix molecules. Syndecan-1 is predominantly expressed on epithelial cells, where its expression correlates with normal epithelial organization. It is also expressed on B lymphocytes at specific stages during their differentiation: precursor B cells in the bone marrow and antibody-secreting cells, including plasma cells, but not mature peripheral B cells. It is thus implicated in mediating B cell-matrix interactions. CD138 expression is also regulated during embryonic development, and the molecule shows a tissue- specific structural polymorphism resulting from different post-translational modifications. The 281-2 antibody may be used to detect the differently glycosylated forms, because it reacts with the core protein. Furthermore, the mAb detects the Syndecan-1 ectodomain which is cleaved from cell surfaces by a metalloproteinase.

Specifications

Specifications

CD138
0.2mg/mL
Monoclonal
Rat
Mouse
NAMRU mouse mammary gland epithelial cell line NMuMG
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
281-2
Flow Cytometry
PE
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
SYND1; Syndecan-1; syn-1; Sdc1; Sstn; synstatin
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