Invitrogen™ CD14 Monoclonal Antibody (UCHM1)

Catalog No.	Quantity
PIMA133348	100 μg

Catalog No. PIMA133348 Supplier Invitrogen™ Supplier No. MA133348

Description

Mouse Monoclonal Antibody

Not suitable for use in immunohistochemistry (paraffin) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.

Specifications

• Antigen: CD14
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Immunocytochemistry
• Classification: Monoclonal
• Clone: UCHM1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide
• Gene: Cd14
• Gene Accession No.: P08571
• Gene Alias: CD 14; CD14; CD14 antigen; CD14 molecule; cd14 monocyte; lipopolysaccharide receptor; lipoprotein receptor; LPSR antibody; monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form; monocyte differentiation antigen CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; myeloid membrane glycoprotein precursor; sCD14; soluble CD14
• Gene Symbols: Cd14
• Host Species: Mouse
• Immunogen: Human Thymocytes followed by peripheral blood mononuclear cells.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 102129342, 697482, 929
• Target Species: Cynomolgus Monkey, Fish, Human, Rhesus Macaque
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a