Invitrogen™ CD140b (PDGFRB) Recombinant Rabbit Monoclonal Antibody (BLR081G)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544354

Catalog No. PIMA544354

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Specifications

• Antigen: CD140b (PDGFRB)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: BBS with 0.09% sodium azide; pH 7.8-8.6
• Gene Accession No.: P09619
• Gene Symbols: Pdgfrb
• Immunogen: Recombinant protein representing the extracellular domain of human Platelet Derived Growth Factor Receptor beta (residues 33-532).
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: BLR081G
• Conjugate: Unconjugated
• Gene: Pdgfrb
• Gene Alias: AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 5159
• Content And Storage: 4°C
• Form: Liquid