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Invitrogen™ CD148 Monoclonal Antibody (MEM-CD148/05), APC
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Catalog No. PIMA528590
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100 Tests
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Catalog No. Quantity
PIMA528590 100 Tests
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Catalog No. PIMA528590 Supplier Invitrogen™ Supplier No. MA528590
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosin phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells. Recommended dilution is for 100 μL of whole blood or 1x10^6 cells in suspension.

CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
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Specifications

Antigen CD148
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-CD148/05
Concentration 0.07 mg/mL
Conjugate APC
Formulation PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene PTPRJ
Gene Accession No. Q12913
Gene Alias AI450271; BET; Byp; CD148; CD148 antigen; colon tumor susceptibility 1; density enhanced phosphatase-1; density-enhanced phosphatase 1; DEP1; DEP-1; HPTP beta-like tyrosine phosphatase; HPTP eta; HPTPeta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type J; protein tyrosine phosphatase, receptor type, J; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; Ptpb2; PTPbeta2; Ptprj; Receptor-type tyrosine-protein phosphatase eta; R-PTP-ETA; RPTPJ; R-PTP-J; Scc1; Scc-1; Susceptibility to colon cancer 1; susceptibility to colon cancer 1, mouse, homolog of
Gene Symbols PTPRJ
Host Species Mouse
Immunogen Human recombinant CD148 (amino acids 1-444).
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5795
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b
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