CD15 Monoclonal Antibody (MCS-1), FITC, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA112651

Catalog No. 01-674-032

Description

This monoclonal anti-CD15 antibody is an IgG3 fraction which will not agglutinate cells, as opposed to most other IgM antibodies which cause cells to aggregate in the cytometer.

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

Specifications

• Antigen: CD15
• Classification: Monoclonal
• Conjugate: FITC
• Gene: FUT4
• Gene Alias: FUTIV, Lewis X, SSEA-1
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2526
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MCS-1
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P22083
• Gene Symbols: FUT4
• Immunogen: White blood cells.
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG3

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov