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Invitrogen™ CD150 Monoclonal Antibody (A12 (7D4)), PE, eBioscience™
Mouse Monoclonal Antibody
$324.00
Specifications
Antigen | CD150 |
---|---|
Clone | A12 (7D4) |
Concentration | 5 μL/Test |
Content And Storage | 4°C, store in dark, DO NOT FREEZE! |
Applications | Flow Cytometry |
Description
Description: The A12 monoclonal antibody reacts with human CD150, an ~70 kDa transmembrane glycoprotein also known as Signaling Lymphocyte Activation Molecule (SLAM). CD150 is expressed by T and B cells and its expression is rapidly upregulated on these cells upon activation. Immature thymocytes and dendritic cells also express this antigen. Signaling through SLAM induces proliferation and cytokine production of T cells and SLAM plays a role in activation of T and B cells. Applications Reported: This A12 (7D4) antibody has been reported for use in flow cytometric analysis. Applications Tested: This A12 (7D4) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.
CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).Specifications
CD150 | |
5 μL/Test | |
Flow Cytometry | |
PE | |
Mouse | |
RUO | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
Q13291 | |
6504 | |
Primary | |
Affinity Chromatography |
A12 (7D4) | |
4°C, store in dark, DO NOT FREEZE! | |
Monoclonal | |
Liquid | |
IgG1 κ | |
Human | |
Slamf1 | |
4933415F16; AA177906; CD150; CD150 antigen; CDw150; ESTM51; IPO-3; RGD1560634; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule; signaling lymphocytic activation molecule family member 1; Slam; SLAM family member 1; Slamf1 | |
Slamf1 | |
Antibody |
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