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Invitrogen™ CD150 Monoclonal Antibody (SLAM.4), Alexa Fluor™ 647
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Catalog No. PIMA544145
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100 Tests
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PIMA544145 100 Tests
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Catalog No. PIMA544145 Supplier Invitrogen™ Supplier No. MA544145
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.

CD150, also known as SLAM (Signaling Lymphocyte Activation Molecule), is a member of the immunoglobulin gene superfamily and plays a crucial role in T cell stimulation and immune cell interactions. It is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells. CD150 expression is rapidly upregulated upon activation, particularly on naive T cells, Th1 cells, and activated B cells, which express the membrane-bound, soluble, and cytoplasmic isoforms of SLAM. In T cells, signaling through SLAM induces proliferation and enhances the interferon-gamma response. SLAM is also involved in adhesion between T cells and antigen-presenting cells, facilitating immune cell interactions. Homophilic SLAM-SLAM binding during B to B and B to T cell interactions is suggested to enhance the expansion and differentiation of activated B cells. CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. It interacts with SH2D1A and PTPN11 via its cytoplasmic domain, playing a role in signal transduction. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP), highlighting its importance in immune regulation and disease pathology.
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Specifications

Antigen CD150
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone SLAM.4
Concentration 0.015 mg/mL
Conjugate Alexa Fluor 647
Formulation PBS with 0.2% BSA and 15mM sodium azide
Gene Slamf1
Gene Accession No. Q13291
Gene Alias 4933415F16; AA177906; CD150; CD150 antigen; CDw150; ESTM51; IPO-3; RGD1560634; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule; signaling lymphocytic activation molecule family member 1; Slam; SLAM family member 1; Slamf1
Gene Symbols Slamf1
Host Species Mouse
Immunogen Human CD150-transfected 300.19 cells.
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6504
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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