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Invitrogen™ CD150 Polyclonal Antibody
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Catalog No. PIPA584809
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PIPA584809 100 μL
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Catalog No. PIPA584809 Supplier Invitrogen™ Supplier No. PA584809
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KVLLPLTYER INKSMNKSIH IVVTMAKSLE NSVENKIVSL DPSEAGPPRY LGDRYKFYLE NLTLGIRESR KE Highest antigen sequence indentity to the following orthologs: Rat - 49%, Mouse - 48%.

CD150, also known as SLAM (Signaling Lymphocyte Activation Molecule), is a member of the immunoglobulin gene superfamily and plays a crucial role in T cell stimulation and immune cell interactions. It is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells. CD150 expression is rapidly upregulated upon activation, particularly on naive T cells, Th1 cells, and activated B cells, which express the membrane-bound, soluble, and cytoplasmic isoforms of SLAM. In T cells, signaling through SLAM induces proliferation and enhances the interferon-gamma response. SLAM is also involved in adhesion between T cells and antigen-presenting cells, facilitating immune cell interactions. Homophilic SLAM-SLAM binding during B to B and B to T cell interactions is suggested to enhance the expansion and differentiation of activated B cells. CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. It interacts with SH2D1A and PTPN11 via its cytoplasmic domain, playing a role in signal transduction. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP), highlighting its importance in immune regulation and disease pathology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD150
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Slamf1
Gene Accession No. Q13291
Gene Alias 4933415F16; AA177906; CD150; CD150 antigen; CDw150; ESTM51; IPO-3; RGD1560634; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule; signaling lymphocytic activation molecule family member 1; Slam; SLAM family member 1; Slamf1
Gene Symbols Slamf1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SLAMF1. Recombinant protein control fragment (Product #RP-108245).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6504
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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