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  6. MilliporeSigma™ CD152 (CTLA-4), Mouse, PE, Clone: BNI3,

MilliporeSigma™ CD152 (CTLA-4), Mouse, PE, Clone: BNI3,

Catalog No. MABF1622 Shop All MilliporeSigma Products
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MABF1622 100 Tests
MABF1621 25 Tests
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Catalog No. MABF1622 Supplier MilliporeSigma™ Supplier No. MABF1622

Description

Mouse Monoclonal Antibody

The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The BNI3 antibody may be used for flow cytometric analysis of intracellular or surface CTLA-4 expression, and is also widely used for neutralization of CTLA-4 when expressed at the cell surface. The BNI3 antibody is reported to be cross-reactive with Baboon, Cynomolgus and Rhesus CTLA-4. Please choose the appropriate format for each application.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD152 (CTLA-4)
Applications Flow Cytometry
Classification Monoclonal
Clone BNI3
Concentration Please refer to lot specific datasheet.
Conjugate PE
Formulation Purified mouse monoclonal IgG2a in buffer containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Gene CTLA4, CD152
Gene Accession No. P16410
Host Species Mouse
Immunogen Immunogen information for this antibody is proprietary information.
Purification Method Purified by size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Form Purified
Isotype IgG2a
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For Research Use Only. Not for use in diagnostic procedures.

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