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Invitrogen™ CD153 Polyclonal Antibody
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Catalog No. PIPA547045
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100 μg
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PIPA547045 100 μg
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Catalog No. PIPA547045 Supplier Invitrogen™ Supplier No. PA547045
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Description

Goat Polyclonal Antibody

In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) CD27 Ligand is observed and less than 1% cross-reactivity with rhCD40 Ligand is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD153
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Tnfsf8
Gene Accession No. P32971
Gene Alias CD153; CD153 antigen; CD30 antigen ligand; CD30 ligand; Cd30l; CD30-L; Cd30lg; CD30ligand; Tnfsf8; TNLG3A; tumor necrosis factor (ligand) superfamily member 8; tumor necrosis factor (ligand) superfamily, member 8; tumor necrosis factor ligand 3A; tumor necrosis factor ligand superfamily member 8; tumor necrosis factor superfamily member 8
Gene Symbols Tnfsf8
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human CD30 Ligand Gln63-Asp234.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 944
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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