CD154 (CD40 Ligand) Monoclonal Antibody (24-31), Functional Grade, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
16-154-838	Invitrogen™ 16154838	5 mg

Description

The 24-31 MAb reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154.

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.

Specifications

• Antigen: CD154 (CD40 Ligand)
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene ID (Entrez): 102138630, 959
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Gene: CD40LG

• Clone: 24-31
• Applications: Flow Cytometry, Functional Assay, Neutralization
• Conjugate: Functional Grade
• Host Species: Mouse
• Target Species: Human, Cynomolgus Monkey
• Gene Accession No.: P29965
• Isotype: IgG1 κ
• Purification Method: Affinity chromatography
• Product Type: Antibody