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  6. Invitrogen™ CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), Super Bright™ 600, eBioscience™, Invitrogen™ 

Invitrogen™ CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), Super Bright™ 600, eBioscience™, Invitrogen™
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Catalog No. 63157942
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63-157-942 100 Tests
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Catalog No. 63-157-942 Supplier Invitrogen™ Supplier No. 63157942
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Description

Mouse Monoclonal Antibody

CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a pleiotropic ectoenzyme and glycosylphosphatidylinositol-anchored molecule that functions both as an enzyme and a receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+, which may play a role in regulating intracellular Ca2+ levels. As an enzyme, CD157 is also referred to as ADP-ribosyl cyclase 2 and DAMP-1, and it facilitates pre-B cell growth. As a receptor, CD157 is thought to initiate a signal transduction cascade upon binding to its putative ligand, leading to the phosphorylation of cytoplasmic proteins, including focal adhesion kinase (FAK). While the mechanism and functional significance of CD157-initiated signal transduction are not fully characterized, its role in cellular signaling is evident. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis, suggesting a link to polyclonal B cell abnormalities observed in the disease. This overexpression in the stromal cell population may contribute to the pathophysiology of rheumatoid arthritis, highlighting the importance of CD157/BST1 in both normal immune function and disease states.
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Specifications

Antigen CD157
Applications Flow Cytometry
Classification Monoclonal
Clone eBioSY11B5 (SY11B5)
Concentration 5 μL/Test
Conjugate Super Bright 600
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Bst1
Gene Accession No. Q10588
Gene Alias 114/A10; A530073F09; ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; antigen BP3; Bone marrow stromal antigen 1; bone marrow stromal cell antigen 1; Bp3; Bp-3; BP-3 alloantigen; Bst1; BST-1; Bsta1; cADPr hydrolase 2; CD157; CD157 antigen; Cyclic ADP-ribose hydrolase 2; leukocyte antigen 65; Ly65; Ly-65; NAD(+) nucleosidase; NAD+ nucleosidase
Gene Symbols Bst1
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 683
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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