Invitrogen™ CD162 Monoclonal Antibody (TC2), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA110117

Catalog No. PIMA110117

Description

This antibody reacts with an extracellular epitope of CD162, a 220 kDa type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a subpopulation of B lymphocytes and CD34⁺ bone marrow cells.

CD162 (PSGL-1) is a 120 kDa homodimer protein found on the surface of leukocytes and platelets. CD162 is known to bind CD62P (P-selectin), CD62L (L-selectin), and to a lower degree CD62E (E-selectin). These interactions play a critical role in leukocyte adhesion, rolling and extravasation. CD162 has been shown to be an important immune marker of T cell exhaustion in chronic viral infections and cancer.

Specifications

• Antigen: CD162
• Classification: Monoclonal
• Conjugate: PE
• Gene: SELPLG
• Gene Alias: CD162; CLA; Cutaneous lymphocyte associated antigen; cutaneous lymphocyte-associated associated antigen; leukocyte cell surface adhesion molecule; P-selectin glycoprotein ligand 1; P-selectin glycoprotein ligand 1 propeptide; P-selectin glycoprotein ligand-1; Psgl1; Psgl-1; Selectin P ligand; selectin, platelet (p-selectin) ligand; Selp1; SELPG; Selpl; SELPLG
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6404
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: TC2
• Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
• Gene Accession No.: Q14242
• Gene Symbols: SELPLG
• Immunogen: Human thymocytes.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1