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Invitrogen™ CD169 Chimeric Recombinant Rat Monoclonal Antibody (3D6.112)
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Catalog No. PIMA547804
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100 μg
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Catalog No. Quantity
PIMA547804 100 μg
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Catalog No. PIMA547804 Supplier Invitrogen™ Supplier No. MA547804
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Description

Rat Recombinant Monoclonal Antibody

Specificity: This antibody specifically recognize mouse CD169, which is a 180-185-kDa member of the Siglec family of macrophage-specific cell adhesion and endocytic receptors interacting with sialylated glycans. This receptor is expressed on a subset of macrophages that are found with high frequency in the spleen, liver, lymph node, and bone marrow. CD169 can also be detected on monocytes in the bone marrow and periphery.

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD169 Chimeric
Applications Flow Cytometry, Immunohistochemistry, Western Blot
Classification Recombinant Monoclonal
Clone 3D6.112
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene SIGLEC1
Gene Accession No. Q62230
Gene Alias Cd169; dJ1009E24.1; macrophage receptor; p210; pSn; SA; SER; sheep erythrocyte receptor; sialic acid binding Ig like lectin 1; sialic acid binding Ig-like lectin 1, sialoadhesin; Sialic acid-binding Ig-like lectin 1; sialic acid-binding immunoglobulin-like lectin 1; sialoadhesin; SIGLEC1; Siglec-1; SN
Gene Symbols SIGLEC1
Host Species Rat
Immunogen Spleen cells from AO rats immunised with thioglycollate-elicted murine peritoneal macrophages (TPM) that had been cutured in mouse serum to induce sheep erythrocyte receptor (SER).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20612
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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