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Invitrogen™ CD170 (Siglec F) Monoclonal Antibody (1RNM44N), eBioscience™, Invitrogen™

Catalog No. 14170295
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14-170-237 2 mg
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Catalog No. 14-170-295 Supplier Invitrogen™ Supplier No. 14170295
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Description

Rat Monoclonal Antibody

This 1RNM44N MAb recognizes mouse CD170, also known as Siglec F. Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types. The cytoplasmic domain of Siglec F contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that initiates intracellular signaling upon ligand binding. Siglec F is expressed mostly on eosinophils and alveolar macrophages and lower levels of this receptor have also been reported on immature myelomonocytic cells. Mouse Siglec F is a functional ortholog of human Siglec 8, however, unlike human Siglec 8, mouse Siglec F is not expressed on mast cells. This 1RNM44N antibody will recognize a formaldehyde-fixed epitope.

SIGLEC-F is a sialic acid-binding immunoglobulin-like lectin predominantly expressed on eosinophils in mice, where it serves as a functional paralog of human SIGLEC-8. It acts as an inhibitory receptor with ITIM motifs that recognize sialylated glycans and can induce eosinophil apoptosis, thereby helping regulate allergic inflammation and immune homeostasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD170 (Siglec F)
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunocytochemistry
Classification Monoclonal
Clone 1RNM44N
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Siglecf
Gene Accession No. Q920G3
Gene Alias SIGLEC-8
Gene Symbols Siglecf
Host Species Rat
Purification Method Affinity chromatography
Quantity 10 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 233186
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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