Invitrogen™ CD171 Monoclonal Antibody (UJ127)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA514140

Catalog No. PIMA514140

Description

MA5-14140 targets L1 Cell Adhesion Molecule in immunohistochemistry (paraffin), immunoprecipitation, and Western blot applications and shows reactivity with human samples. The MA5-14140 immunogen is homogenous suspension of 16 week human fetal brain. MA5-14140 has been successfully used in immunohistochemistry analysis of NCAM1 in mouse E16.5 frozen lung sections.

L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Specifications

• Antigen: CD171
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P11627, P32004
• Gene Symbols: L1CAM
• Immunogen: Homogenous suspension of 16 week human fetal brain.
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: UJ127
• Conjugate: Unconjugated
• Gene: L1CAM
• Gene Alias: antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 molecule; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM L1; NCAML1; N-CAML1; N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; NILE; S10; sCD171; sL1 CAM; sL1CAM; soluble CD 171; soluble CD171; soluble L1 CAM; soluble L1CAM; SPG1
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 16728, 3897
• Content And Storage: 4°C
• Form: Liquid